Sedakov I. Selective intra-arterial polychemotherapy in combined treatment of primary inoperable breast cancer

Object - patients with primary-inoperable and metastatic breast cancer who were treated with selective intraarterial polychemotherapy as part of treatment. Aim - to elaborate and introduce into clinical practice program of complex treatment which includes selective intraarterial polychemotherapy, radiational therapy and hormonotherapy, providing improvement of immediate and follow-up results. Methods - anatomical, morphometrical, ultrasound, roentgenological, radioisotope, immunohistochemical, immunomorphological, clinical laboratory, statistical. Results - original techniques of intraarterial polychemotherapy of primary breast cancer have been elaborated and introduced into clinical practice, that allows to widen indications for surgical operations as radical ones, to increase reccurence-free period and total survival rate of paients with distant metastases and locoregional reccurences. Novelty - optimal surgical approaches for catheterization of main arteries supplying breast and soft tissues of thoracic wall have been substantiated for the first time; practically oriented classification of vessel tree types of internal thoracic artery have been elaborated; it was proved that selective intraarterial polychemotherapy combined with radiational therapy provides subtotal ruin of tumoral parenchyme in that group of patients, decreases cataplasia of tumor cells, intensification of connective tissue maturation, increase of vascularization rate, optimzies population and functional integrity of immunocompetent cells. It was introduced in Donetsk Regional Oncological Center, town and regional oncological centers, Institute of Oncology of Ukrainian Academy of Medical Science. Branch- medicine.