Brazhko O. Biologically active derivative quinoline and acridine with nitrogen- and sulfursubstantional by functional groups

Derivative of quinoline and akridine with nitrogen- and sulfursubstantional functional groups. Search of new biologically active compounds among derivate quinoline and acridine. Chemical synthesis, IR-, UV-, PMR-spectroscopy, mass-spektrometry, TLC, toxicological and biochemical methods, computer prognostication. The synthesis of derivative both quinoline and akridine with nitrogen- and sulfursubstantional functional groups is carried out. It has been shown that investigated derivative quinoline and acridine in the majority relate to moderately toxic, few toxic or practically nontoxic to connections and have a wide spectrum of biological activity. Derivative quinoline and acridine in conditions of generation free radical scavenger of oxidation show properties of "traps" superoxidanione in a aqueous medium, catch a hydroxyl radical in heterogeneous systems, reduce a level peroxides of connections, brake education of the active forms oxide of nitrogen, show protector action rather ferments antiradical and antioxidant of protection, reduce the contents of products free radical scavenger oxidation. Normalize basic parts carbohydrational and power exchange, protect stocks endogenous antioxidants. The convenient method of synthesis is developed; the physico-chemical properties are investigated and are carried out until clinical of research on biologically active substation ("Chinothinum") with antioxidant and cerebroprotection activity.The sphere of the use is bioorganic chemistry, pharmacology.