Marushko T. Juvenile rheumatoid arthritis: features of diagnostics and treatment

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0506U000289

Applicant for

Specialization

  • 14.01.10 - Педіатрія

18-05-2006

Specialized Academic Board

Д 26.003.04

Bogomolets National Medical University, Ministry of Health of Ukraine

Essay

The thesis is devoted to improvement of diagnostics, medically-rehabilitation measures, directed on the increase of efficiency of treatment, warning of intensifying and progressing URA. In the process of inspection the features of URA flow are discovered at the children of different age groups. There were exposed some features of the structurally-functional state of bone tissue, were discovered certain enhanceable levels of autoantibodies to most tissues antigens, the level of cytokines (neopterin, TNF, IL-10) in a blood and synovia. In work the therapeutic algorithm of URA is presented, which includes the differentiated setting of base therapy, NAIP, glucocorticoids, antiresorbtive preparations, taking into account a form, activity, flow of disease which to prevent intensifying of pathological process, considerably improves a prognosis of URA.

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