Object of the study: Disorders of structural functional state of the bone tissue in children. Purpose of the study: To improve the methods of diagnosis and prevention of metabolic disorders of structural-functional state of the bone tissue in children depending on the age, gender, physical development, presence of chronic somatic pathology by means of investigation and development of regional ultrasound parameters, determining risk factors and prognosis of osteopenia. Methods of the study: Clinical epidemiological, anthropometric, instrumental, biochemical, clinical statistical. Practical significance: Application of the developed diagnostic and prognostic algorithms allows to approach differently ultrasound dosimetry and the study of bone tissue remodeling, which promotes early diagnosis and prevention of the structural-functional state of the bone tissue in children and teenagers. Diagnostic and prognostic significance of a number of factors of development of osteopenia disorders was determined. Thefindings of the research are important for different levels of health protection: primary care – standards of preventive and diagnostic aids for pediatricians and general practitioners, secondary care - for specialists of general hospitals it is recommended to use diagnostic standards for children with chronic somatic diseases, tertiary (specialized) care – therapeutic diagnostic center for metabolic disorders of the bone tissue was organized. Regional densitometry register was compiled. Novelty of the obtained results. Systemic investigation of the regularities of forming the bone mass peak in children and teenagers with the account of a complex of factors was performed. Standard regional parameters of qualitative densitometry for evaluation of structural functional state of the bone tissue depending on the age, gender, level of physical development of children of Kharkiv region were determined. Diagnostic significance of genealogical, ante- and postnatal risk factors of –metabolic disorders development wasestablished. This was used to improve early diagnosis of osteopenia and osteoporosis. For the first time, diagnostic significance of determining the amount of conventionally toxic micro- and macroelements in the hair of children with osteopenic syndrome was investigated. Systemic measures on prevention of osteopenia in children were substantiated. Degree of introduction: The findings of the research were introduced to the work of pediatric department of Institute of Spine and Joint Pathology, city clinical hospital No. 17 (Kharkiv), regional children’s specialized hospital, city therapeutic diagnostic center of bone tissue metabolic disorders (Kharkiv), pediatric out-patient hospital (Merefa), city hospital No. 13, pediatric department of hospital of Shevchenko station (Odessa Railroad), as well as teaching process f pediatric, general clinical and epide-miological departments of Kharkiv State medical University. Sphere (area) of application: medicine, pediatrics.
