Pyvovarenko V. Synthesis, structure and properties of multi-channel fluorescence probes on the basis of 1,3-diarylideneketones, dicyclopenta[b,e]pyridines and 3 hydroxychromones

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0507U000514

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

18-09-2007

Specialized Academic Board

Д 26.001.25

Taras Shevchenko National University of Kyiv

Essay

Development of multi-channel fluorescence probes on the basis of mentioned in the title classes of dyes was implemented. Multi-channel fluorescence probes report about the events in studied object by several channels, each presented by separate region of excitation or emission spectrum of the probe. This allows to collect the most precise and detailed information about the object. A new group of fluores-cence dyes from 3,5-diarylidenedicyclo-penta[b,e]pyridines was synthesized. The properties of their representatives were studied. A series of 3-hydroxychro-mone derivatives of prescribed structure were synthesized. The correlations in the structure of dye molecule and its parameters of absorption and emission bands, as well as with the nature of microsurroundings were estimated. The probe for determination of adenosine triphosphate in aqueous solutions, in its physiological range of concen-trations was elaborated. The representatives of diflavonols – a new class of dyes with two proton transfer systemswere synthesized, and their fluorescence properties were studied.

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