Kovzun O. Molecular mechanisms of signal transduction of adrenal cortex regulators

Object: intracellular signaling systems which mediated signal transduction of adrenocortical function. Aim of the work: to investigate the main steps of the action of adrenocortical function regulators and modulators, such as ACTH, estradiol, potassium ions, NAE. Methods: biochemical, molecular biological, radioimmunological, statistical. Theoretical and practical results: the research of the molecular mechanisms of regulation of adrenocortical function, some interactions and transregulation influences between different second messenger systems, which mediate intracellular signal transduction of agonists and provide functional activity of adrenocortical cells are discussed as multifactorial conception. It was established that ACTH caused significant antiapoptotic effect and NAE caused proapoptotic effect in human adrenal cortex. The role of protein kinase C isoforms and receptor tyrosine kinases in tumorogenesis of adrenal cortex is described. It may be argued that some isoforms of protein kinase C might be involved in oncogenesis in human adrenal gland. Novelty: for the first time shown analysis of protein kinase C isoforms distribution in pathological condition of adrenal cortex. It was shown that cAMP dependent signaling system, protein kinase C are involved in signal transduction pathways of estradiol in the adrenal cortex. It was investigated apoptosis in adrenal cortex after influence of ACTH and N-acyletanolamines. Degree of introduction: scientific articles and reports, the results of these investigations were offered to use fir the lead through of educational process. Sphere of application: endocrinology.