. Object of the study: chronic nonspecific nonulcerative colitis in children (CNNCc). Purpose of the study: an increase in the efficacy of the diagnosis, the devision of the formation concept, the making of a clinical-morphological classification and the substantiation of the princi-ples for prophylaxis and treatment of CNNCc on the basis of the study of risk factors for the development of the disease, clinical-morphological peculiarities of its course, the state of biocenosis, motility, tonus and haemodynamics of the colon. Methods of the investigation: clinical-instrumental examination of the colon (rectoscopy, irrigography, histology), determination of the colon tonus and motility (electromyography), regional haemodynamics (rheorectography), anti-inflammatory cytokine level; macroscopic, microscopic and bacteriological (intestinal biocenosis) study of faeces, thermographic examination of the an-terior abdominal wall, analytical-statistical method of processing the results obtained. Theoretical and practical results: criteria and algorithm for prognosticating CHHC development were devised, thereby mak-ing it possible to form, with a high reliability (> 95 %), an in-creased risk group for the appearance of this disease, as well as to increase the efficacy of primary prophylaxis in children of this group owing to neutralization of significant prognostic factors. A modern clinical-morphological classification of CNNCc was made and introduced into practical health protection; it makes possible to objectively characterize different aspects in the disease course and formulate its complete clinical-morphological diagnosis. Cri-teria for the diagnosis and differential diagnosis of inflammatory and functional diseases of the colon in children were created and introduced into practical health protection, thereby making it pos-sible to increase the efficacy of preclinical diagnosis of CHHCc. Principles of differentiated correction of CNNCc with regard for a degree of expression of inflammatory changes in the mucosa, the character of disorders in the motility and tonus of the colon, the presence of intestinal biocenosis disturbances were created and in-troduced into practical health protection, thereby making it possi-ble to increase the efficacy of medical measures. Novelty: for the first time in the paediatric practice, a complex study of the state of the colon in CNNCc was conducted with help of instrumental, morphological, immunological and bacteriologi-cal methods of examination. The study made it possible, from all the aspects, to characterize risk factors, mechanisms of formation, peculiarities in the clinical course of the disease, to substantiate a concept of CNNCc development, to prove its self-sufficiency as a nosological form and determine its place in the structure of colon diseases in children. For the first time, the assessment of the state of the colon was simultaneously accompanied by the study of pe-culiarities in its haemodynamics, the state of biocenosis and the level of anti-inflammatory cytokines in the blood serum, thereby making it possible to significantly supplement the notion of CNNC pathogenesis. For the first time, criteria for prognosticating the development of chronic intestinal diseases in children were es-tablished and an algorithm for prognosticating the development of CNNC on the basis of a mathematical analysis of risk factors was suggested. A clinical-morphological classification of CNNCc was made, thereby making it possible to assess different parameters of the disease from modern viewpoints. Principles of preventing and treating CNNCc with regard for the mechanisms of its formation, the clinical-morphological form of the disease, the state of the intestinal tonus, the motility, biocenosis and haemodynamics of the colon were scientifically grounded. Degree of introduction: on the materials of the research, methodological recommendations “Chronic nonspecific nonulcerative colitis in children: Etiology, pathogenesis, classification, clinical manifestations, diagnosis, treatment, dispensary observation” were published; they were approved by the Ukrainian Research Centre of Scientific Medical Information and Patenting-Licensing Work and agreed by the director of the Department for Organization and Development of Aid to Population of the Ministry of Health of Ukraine Moiseenko R.O. (Kyiv, 2007). Results of the research were introduced into the work of a number of children’s medical establishments of Ukraine: Kharkiv City Children’s Gastroenterology Department on the base of Kharkiv City Clinical Hospital No. 19, Kyiv City Children’s Gastroenterology Centre on the base of Children’s Hospital No. 9 of Podolsk District of Kyiv City, city and regional children’s hospitals of the City of Sumy, Reznik First Children’s City Hospital and the Regional Children’s Clinical Hospital of the City of Odesa, Chernivtsi Regional Children’s Clinical Hospital. The research results, dealing with problems in etiology, pathogenesis, classification, peculiarities of the clinical course, diagnosis, differential diagnosis and principles of correction of CNNCc are used in the teaching process at the Department of Paediatric Gastroenterology and Study of Nutrition of Kharkiv Medical Academy of Postgraduate Education. Sphere of application: medicine, paediatrics.
