Prikhodchenko V. Optimization of the early diagnosis and secondary preventive examination of the mamma's gland cancer in general medical service

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0508U000463

Applicant for

Specialization

  • 14.01.07 - Онкологія

23-06-2008

Specialized Academic Board

Д 11.600.01

Essay

Object of study is risk factors of development of cancer of the breast gland, characteristive for women of region; diagnostics of early structural-morphological pathologies in a fabric of the breast gland; thermobiological processes in a fabric of the breast gland in norm and at pathology; system of diagnostics by means of selective screening, revealing and treatment of pretumoral states at the women of "risk group". The purpose is to develop organizational principles, methodical approaches and medical technologies which improve the early diagnostics and secondary preventive maintenance of cancer of the breast gland, reduce quantity of neglected stages, raise quality of revealing, regular medical cheek-up and treatment of "risk groups". The methods are clinical and tool (thermоmammоgraphical, mammоgraphical, ultrasonographical, aspiration biopsies, threpanbiopsies, exceptional biopsies, cytomorphology) ones, as well as questioning and working out of computer programmes, those ones of statistical analysis and mathematical (neuron net) modeling. The novelty lies in the fact that the algorithm of selective screening in diagnostics of diseases of the breast gland at applying of women to a polyclinic of the general medical network has been developed; by means of the model of artificial neuron net the most possible risk factors that influence the occurrence of cancer of breast gland heve been singled out; the method of the contact digital of thermоmammоgraphy, with the help of with four thermоmammоgraphical forms of cancer of the breast gland were singled out has been officially approved and introduced into clinical practice; the early signs of thermobiological infringements in a fabric of the breast gland have been established. The results lie in the fact that the elaboration of organizational methodical approaches of granting mammоgraphical help, introduction of the algorithms of biographical and selective screening, application of criteria of formation, supervision and treatment of "risk groups" have made itpossible to improve considerably the revealing at the early stage both of non-malignant diseases of the breast gland, and a cancer. The possibility of application of the contact termographic for control over the efficiency of treatment dishormone infringements the been established; the computer program for revealing and singling out of "risk groups" has been offered for practical application. The results hav been put into practice in the central hospitals №2 "Energetic", №3, №6, №17, №18, №21, №24 and №26 of Donetsk, in the Donetsk Regional Antineoplastic Centre, in the Lugansk Regional Clinical Oncological Centre. Branch - medicine (oncology).

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