Lypska A. Dose formation, the character of early effects and risks of distant effect in animals and long-term activity of Chernobyl radionuclides release.

This dissertation is devoted to the research of the important key problems of actual radiobiology-formation of absorbed and effective doses, early response-reaction of the organism and delayed effects due to the extended Chernobyl radionuclides release and risks in comparison to short-term intake and single external irradiation to the animal. For the first time the kinetics of Cs-137 and Sr-90 in the organism of the laboratory rats are presented and performed by using multichamber models. The function of the isotopes retention in organs and tissues and value of biokinetic constants allowed calculating and utilizing more precise absorbed and effective doses, which were determined experimentally. Firstly to estimate the influence of radiation indexes and regime of irradiation the proposed conception "response reaction of the organism" as quantitative integral index of the biological effectiveness of the ionized radiation. For the first time in the complex experiment it was stated that long term intakeof Chernobyl radionuclides release in organism causes sufficient risks of than single external exposure at equally effective doses. The proposed hypothesis, bases on quantitative evaluation, the value of response reaction of organism due to early radiogenic distortion and delayed radiation effects can prove that the value of biological effectiveness at different regimes of irradiation to animals are coordinated between themselves as long-term internal > short-term internal >external irradiation.