Sokolova I. Features of a pathogenesis, clinic, diagnostics and treatment of generalized periodontitis the patients with hereditary predisposition to it depend Кількісні характеристики дисертації

The thesis deals with clinical and genetic aspects of one widespread stomatology diseases – generalized periodontitis (GP). Accoding to the date of patients’ examinations it has been determined two variants of clinical course of these disease depend on hereditary predisposition: unfavourable and favourable. The microbiological and immunological investigations have confirmed the difference of clinical forms of the pathology. The work substantiates genetic factors importance in GP formation and progress. It has been proved that GP is a hereditary-determined disease. In this disease family aggregation with GP accumulation among І-degree relatives and its predominant uncertainty revealing in females is observed. Multifactorial model of GP inheritance, which formation is determined significantly by hereditary factors, has been proved. The features of immunogenetic (І and ІІ class antigens of HLA system) and dermatoglyphic parameters allocation in patient with GP and that depends hereditary predisposition. The algorithm of capability of origin and nature of a course GP prediction was elaborated on the basis genetic parameters and high effectiveness of the suggested criteria for the disease prognosis was determined. The methods of treatment of GP the patients with hereditary predisposition to it depend, have been suggested and approved in clinics. It has been determined that using of improved diagnostic and therapeutic complexes reduced quantity of complications, relapses and allows to raise the effectiveness of treatment process.