Zhuravel I. Synthesis, chemical properties and biological action of 7-azacoumarins

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0509U000180

Thesis Registration Form

0509U000180.pdf

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

12-03-2009

Specialized Academic Board

Д 64.051.14

V.N. Karazin Kharkiv National University

Essay

Investigation object: purposeful synthesis of derivates 7-azacoumarine and products of their transformations, chemical and biological properties of the synthesized compounds. Aim: development of methods of synthesis of derivates of 2H-pyrano[2,3-c]pyridine and pyrido[4',3':5,6]pyrano[2,3-d]pyrimidine, study of their structure and properties, estimation of potential pharmacological activity and determination of biological action. Methods: synthesis, spectral researches, virtual and biological screening. The author proposed the strategy for synthesis of 2Н-pyrano[2,3-с]pyridine derivatives, studied the their potential for construction of assemblies of heterocycles and condensed heterocyclic systems. The methods for synthesis of 2Н-pyrano[2,3-с]pyridine and pyrido[4',3':5,6]pyrano[2,3-d]pyrimidine derivatives combinatorial libraries, which appeared to be suitable for high-throughput biological screening, were developed. Some models of virtual screening for prediction synthesized compounds activity for biological targets as well as pharmacological activity were proposed. The results of pharmacological study of the compounds obtained were discussed; the QSAR-analysis the screening results have been carried out. A sphere of introduction is medical chemistry, synthesis of biological active compounds.

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Автореферат--автореферат-титул.doc

Автореферат--автореферат.doc

Автореферат--автореферат.doc

Диссертация--Glava-1--Glava-1.1.doc

Диссертация--Glava-1--Glava-1.2.doc

Диссертация--Glava-1--Glava-1.3.doc

Диссертация--Glava-1--Glava-1.4.doc

Диссертация--Glava-1--Glava-1.5.doc

Диссертация--Glava-2--Glava-2.doc

Диссертация--Glava-3--124.DOC

Диссертация--Glava-3--Glava-3-1.doc

Диссертация--Glava-3--Glava-3-2.DOC

Диссертация--Glava-4--Glava-4.doc

Диссертация--Glava-4--Glava-4.doc

Диссертация--Glava-5--179.doc

Диссертация--Glava-5--Glava-5-1.doc

Диссертация--Glava-5--Glava-5-2.doc

Диссертация--Glava-6--Glava-6.doc

Диссертация--Glava-7--Glava-7.doc

Диссертация--Literature--Литература.doc

Диссертация--Вступ--Вступ-1.doc

Диссертация--Вступ--Вступ-2.doc

Диссертация--Выводы--Загальні_висновки.doc

Диссертация--Приложения--Таблиця-Д-2.doc

Диссертация--Приложения--Таблиця-Д-3-1.doc

Диссертация--Приложения--Таблиця-Д-4.doc

Диссертация--Приложения--Таблиця-Д-5-2.doc

Диссертация--Приложения--Таблиця-Д-7.doc

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