Tertishniy S. Morphogenesis of changes in the nuclears of cardiorespiratory center in brain stem at the hemisphere strokes

Investigations of intracerebral hemorrhages and hemisphere infarction complicated by secondary brain stem syndrome in dead patients and in experiment on animals (white rats) have revealed mechanisms of development, pathomorphological and clinical displays of damage of cardiorespiratory center's ( CRC) structures of brain stem. In research were used such methods as histological, histochemical, immunohistochemical analyses, electron microscopy, computer morphometry, biophysical investigation of general and bonded water, statistic analysis with parametrical criteria and correlation analysis. It has been established that damage of CRC at patients with hemisphere strokes are characterized by definite reasons, pathomorphological and clinical signs. It has been revealed that subtotal hemorrhagic-necrotic changes with distruction of CRC nuclei appear at hemisphere strokes complicated by secondary brain stem syndrome in conditions of quick transtentorial brain dislocation at tectum of mesencephalon and at top third of tegmentum. Ischemic damages in CRC structures of anatomically saved brain stem dominate at slow axial dislocation due to microcirculation disturbances, brain stem edema and stem caudal dislocation, spasm of stem arterioles and haemodynamic insufficiency. The research shows distinctions and gives quantitative estimation of processes of structural reorganization of neurons of CRC nuclei. The state of conductive tracts and mediators of CRC structures have been investigated in research. Quantitative characteristics of glial-neuronal interactions, edema changes, microcirculative and angiospastic disturbances have been established. Tanatogenically important clinical-morphological displays of CRC damage at complicated hemisphere strokes have been found and can be used in pathomorphological diagnostics of death courses.