Zhylchuk V. Personalization of antitumor therapy of patients with breast cancer: molecular aspects and clinical efficacy

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0510U000123

Thesis Registration Form

0510U000123.pdf

Applicant for

Specialization

  • 14.01.07 - Онкологія

27-01-2010

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

The dissertation is dedicated to actual oncology problem - the development of ways of increasing the efficacy of breast cancer drug treatment based on its individualization. It is shown that usage of chemohormonal therapy schematics considering the expression of drug resistance associated molecular markers and steroid hormone receptors (RE, RP), and Her-2/neu in the tumor cells of each patient slightly increases the efficacy of anti-tumor chemohormonal therapy. It is determined that individualized chemohormonal therapy is effective even in "thrice-receptor-negative" tumor patients. It is proven that the interferon supplement of different therapy schematics is reliably increasing their efficacy, especially in case of long-term cytokine administration.

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Files

avtoreferat Zhylchuk.doc

avtoreferat Zhylchuk.doc

dissertation Zhylchuk.doc

dissertation Zhylchuk.doc

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