Danchenko O. Association between antioxidative status of domestic goose and external factors related to farming

The dissertation is focused on the evaluation of antioxidant protection mechanisms in domestic species of goose under several external factors related to farming (including transportation and adaptation to new housing conditions). The conducted research provides a rationale for a new approach to the assessment of the pro-antioxidant equilibrium status in goose. It is established that the antioxidant status depends on both the levels of endogenous antioxidants and efficiency of their interactions. Experiments on two species of goose (Italian and Gorkovskaya) and Muscovy ducks have shown that the physiologically caused stress in birds is associated with a declined balance among components of antioxidant protection (AP) system at all levels. The peak of stress on AP system in goose, both in terms of activity of individual components of the system and their interaction, is observed at the time of development of juvenal and planimetric feather. Therefore the technological manipulations causing additional stress to AP system in goose are not advisable during this period of development. Furthermore, it is proved that the general balance of AP system parameters in the goose liver tissue is inversely correlated with the Е-vitamin levels. An additional mechanism of AP system activation consists of enhancing the balance among PA system components, which is observed under the low levels of antioxidants in the tissue. Development of an adaptation response to stress factors is associated with an increasing role of non-enzyme components in the AP system. It has been proved necessary to use antioxidant supplements in farming of hypovitamin E goose using a combination technology. Comparison of mechanisms of action among synthetic, combined and biogenic antioxidants (distinole, stibel with dimethilsulfoxide combo and stibel, respectively) showed that all of the above antioxidants activate AP system. However, the mechanisms of activation differ among the three agents: synthetic antioxidants enhance the antioxidative status by activating endogenous antioxidants, while the biogenic stibel increases functional efficiency of components of the AP system.