Oleynyk T. Modern pathogenetic methods of initial stages of diabetic retinopathy prophylaxis and treatment (experimental and clinical investigations).

Object: diabetic retinopathy. Purpose: rising efficiency of prophilaxis and patient's treatment with initial stages of diabetic retinopathy by metabolic correction of oxialdehyd's level, carbohydrate-phosphoric metabolism, antioxidatic system on the basis of pathogenetic patterns revealing in development of diabetic retinopathy. Methods: ophthalmologic, biochemical, experimental, clinical, methods of the statistical analysis; ophthalmoscope "Omega", fundus camera "Visucam Zeiss". For the first time retinal pigment epithelium damage at ultrastructural level as membrane structure labilization is revealed at early terms experimental streptozotocin induced diabetes damage. The scientific data which confirm a role of methylglyoxal in development of diabetic damage of retina are added. Scientific data about disturbance of physiologic balance between intensive formation of free radicals and retinal antioxidant system activity at early terms of development streptozotocin induced diabetes have been dilated. For the first time it is established that functionally correlated coenzymes have normalizing effect on metabolic disturbances in the retina at streptozotocin induced diabetes. For the first time it is established too that application of preparations of amino acids precursors glutathione and benphothiamin poccesses normalizing action on retinal metabolism. Scientific knowledge concerning diabetic retinopathy pathogenesis 's links are dilated too. For the first time the possibility of normalizing influence on the damaged physiologic balance between intensity of free radicals formation and glutathione antioxidatic system activity, condition of carbohydrate-phosphoric exchange and the raised level of oxialdehyds was proved in patients with DM type 2 with initial stages of diabetic retinopathy. New methods of early signs diabetic retinopathy treatment were worked out and introduced, as a result non- proliferative diabetic retinopathy stabilization was achieved more than in 4 times and in 2,5-3 times to stay initial implications of diabetic retinopathy in comparison by control group. Results of work are introduced in 10 leading ophthalmologic medical institutions of Ukraine and are included in programs of lectures and practical training at faculty of ophthalmology in 8 medical institutions of Ukraine. Sphere of application - medicine, ophthalmology.