Nishkumay O. Ischemic heart disease and systemic osteoporosis in women in postmenopause period: clinic-pathogenic peculiarities, diagnostic, treatment.

The work is devoted to the study of clinic-pathogenic peculiarities and treatment of ischemic heart disease (IHD) in combination with systemic osteoporosis (SOP) in post menopause. 411 women in post menopause were investigated. Atherogenic hyperlipoproteidemia of IIb-type was revealed in women with SOP. Increasing of ET-1 level and decreasing of the content of final metabolites NO2, NO3 in blood was remarked. More severe dysfunction of cytokine profile of blood (CPB) was determined in the group of women with IHD and SOP at the women in post menopause as well as severe disturbances of structural-functional condition of bone tissue. Correlation analysis determined negative correlation of osteoprotegerin with Tr, Chol, Very Low density cholesterol (VLDC), lipomatosis of vessels, IL-1?, TNF-?, IL-6, IL-8, ЕТ-1 level and moderate positive correlation with osteocalcini and T-score. Correlation links between indices that characterize bone mineral density (BMD) and lipid exchange were established. Experimental research showed that long lasting hypercholesterolemia was accompanied with changes of ultrastructure of mineral conponent of bone and lowering of mechanical density of long bones and increasing of their fragility. Usage of the combination of simvastatin, calcium and vitamin D3, strontium ranelate positively influences on the state of lipid exchange, endothelium function, CPB, level of osteoprotegerin and bone formation and resorbtion markers. Gained data allow to improve diagnostic and treatment algorithm of dealing with women in post menopause, carrying on densitometry investigation of the women in case of revealing of hyperlipoproteidemia.