Ostrovs'ka S. Effects of ionizing radiation and salts of heavy metals in cardiovascular system (experimental study)

Thesis is devoted to the study of patterns of effects of separate and combined impact of a single total ?-irradiation doses in the range 0,5-6,0 Gy, salts of cadmium and lead in the state of pro-and antioxidant balance morphological and functional condition of kidneys, heart, heart vessels and aorta of rats conditions for modeling renal hypertension. Found that in rats most sensitive to ionizing radiation, salts of cadmium and lead in kidney and heart is the arterial-capillary vessel, and their damage leads to significant disturbances of microcirculation. Determined that the initial elevated blood pressure and heart rate is a risk factor for hypertensive state with steadily elevated diastolic blood pressure due to the total ?-irradiation and malignant forms of renal hypertension given its modeling. Combined effect of ionizing radiation, chlorinated compounds of cadmium and lead on the background of a model ischaemisation kidneys with stable hypertension results in significant violations of pro-antioxidant balance mainly due to depletion of antioxidant protection. Heavy metals potentiate the effects of radiation-induced changes in the cardiovascular system. Combined Metals potentiation of radiation-induced changes in the cardiovascular system, which lead to the development of hypertension, is realized in two ways: increased kidney function renin-angiotensin system and proximal tubular dysfunction, which accelerates the elimination of calcium. Shown radioprotection effectiveness of ?- carotene on cardiovascular system of rats exposed to simulated renal hypertension.