Object - transformation of organic and mineral constituents at the production of organic fertilizers and organo-mineral fertilizers; efficiency of their application in short-term crop rotations; transformation of the humus state of soils and their power-hungryness at the different systems of fertilizer and treatment. Purpose - theory and technologically to ground the processes of production of organic and organo-mineral fertilizers from local raw material on the basis of the managed bioconditioning, to define agrochemical efficiency of their application in short-term crop rotations, to set conformities to law of transformation of the humus state of chernozems and their power-hungryness at the different systems of fertilizer and treatment. Methods - the field, vegetation, laboratory-analytical. The results of researches treat the methods of the statistical processing of data. Theoretical results - theoretically grounded the process of organic and organo-mineral fertilizers production from local raw material with determination of agrochemical efficiency of their application in short-term crop rotations; is worked out the normatively-methodical base of handling with local raw material and fertilizers on its basis; are set conformities of transformation of humus state of chernozems and their power-hungryness at the different systems of fertilizer and treatment of soil. Practical results - developed and put in place a national standard of Ukraine "Organic and organo-mineral fertilizers. Methods of determining of humic acids" (7083:2009), which is recommended for the implementation to the Regional State Centre for Soil Fertility and Quality Production, and to measurement (analytical) laboratories that conduct monitoring of organic waste, organic and organo-mineral fertilizers and humate containing growth plant stimulants. For the Regional Research and Production Center of Standardization, Metrology and Certification during the examination of specifications for organic and organo-mineral fertilizers and development of production schedules for their production is recommended to use the national terminology standard of Ukraine "Organic and organo-mineral fertilizers. Terms and definitions" (4884 : 2007). Households and companies, which through their activities generate organic waste, it is recommended to introduce the technology of production and the use of organic and organo-mineral fertilizers, plant growth stimulants. In the regions of Ukraine with the natural deposits of organic raw material (peat, brown coal, sapropel) it is recommended to inculcate technologies of production of liquid humate containing growth plant stimulants and organo-mineral fertilizers on their basis. Novelty - theoretically and technologically substantiated the process of production of organic and organo-mineral fertilizers from local raw materials based on a conceptual model of transformation humus compounds at its composting and principles of making of organo-mineral fertilizers. At the first time are developed and standardized terms and definitions in the field of organic and organo-mineral fertilizers and organic waste with fertilizer properties; nomenclature of indicators of their quality. Are developed classification groups of local raw materials, allowing to orient producers and consumers in use of the raw materials and fertilizers based on it. Scientifically proved the feasibility of introducing complexants and specialized additives to organo-mineral mixture. It make possible to create the fertilizers with improved agrochemical properties and increased physiological activity. At the first time was developed the method of calculation of consumption rate of components at production of organo-mineral fertilizers, which allows to develop and improve the fertilizers composition for specific soil and climatic conditions, grown crops , considering the timing and methods of application. Substantiated the advantages of organo-mineral fertilizers in comparison to the use of mineral and organic fertilizers. Degree of application - the substantive provisions of theoretical and experimental researches are using for planning and industrial production of new kinds organic, hard and liquid organo-mineral fertilizers, their realization in an agricultural production in Kharkov, Donetsk, Zaporizhzhya, Dnepropetrovsk, Poltava, Lviv and Chernivtsi areas, and also in the educational process of higher educational establishments of III-IV of level of accreditation, that confirmed by the corresponding acts of introduction. The results of these researches entered to normative and normatively-technical documents (national standards, technical requirements) on a production and application of organic and organo-mineral fertilizers. The field is agriculture.