Deyeva Y. Peripheral and central vestibular disorders in patients with diabetes mellitus (clinical and experimental study)

The thesis focuses on improving the efficiency of diagnosis, treatment, rehabilitation and prevention of vestibular dysfunction in patients with diabetes basing on experimental modeling of the pathological process in the inner ear and identifying clinical and electrophysiological disturbances of different parts of the vestibular system. Based on the examination of 591 patients with diabetes mellitus types 1 and 2 were determined to identify the central and peripheral vestibular disorders in 78.8 % of patients. Identified in 46.3 % of patients with metabolic syndrome vestibular disorders suggest common pathogenetic orientation vestibular damage in metabolic disorders. On a model of diabetes vestibular and auditory data in experimental rats were identified and protective effect of succinic acid on the structure of the inner ear was proved. It was found that vestibular disorders are one of the earliest complications that occur in patients with diabetes and can serve as markers of diabetic complexities of the process. A treatment regimen and rehabilitation of vestibular dysfunction in diabetic patients using a specially designed set of exercises on stabilographic platform and method hypoxytherapy. The expediency of the use of drugs succinic acid in treatment of patients with vestibular dysfunction with diabetes. On the basis of vestybular parameters and assess their diagnostic value Prognostic criteria improve vestibular function in diabetic patients with VD. The research extends the appearance of the mechanisms of vestibular dysfunction in patients with diabetes, which will improve medical and rehabilitative tactics for improving the quality of life of patients.