Kharchenko V. Nonalcoholic steatohepatitis: clinical, metabolic and immunological aspects, the method of treatment during its combination with arterial hypertension

The results of the complex clinico-laboratory, biochemical, immunological and instrumental investigations of 250 patients with nonalcoholic steatohepatitis (NASH) in combination with arterial hypertension (AH) are summarized in the dissertation. The main group with 125 patients received differentiated diet enriched with lecithin, omega-3 fatty acids, vitamin C, complex vitamins - Vita-B-Plus and antioxidants and Metabolics - Lipoflavon, Citrarginine, Ursofalk, Cardonat, Magne B6 and moderated aerobic physical exercises were appointed. The positive effects of the developed treatment on the clinical manifestations of the disease were noted, namely, a body weight decrease, disappearance of asthenic syndrome, improvement of cardiovascular system condition and the quality of life. Under the influence of the developed treatment significantly improved the status of liver parenchyma and vessels. Developed treatment combined with increased physical activity in patients with NASH in combination with AH reduces the biochemical markers' normalization time of the functional state of liver and lipidogram, improves processes of oxidative phosphorylation; has a normalizing effect on the level of HbA1c, decreases the concentration of homocysteine in the blood and reduces the EMA, helps to eliminate the imbalance between the processes of anabolism and catabolism in the extracellular matrix of hepatic tissue, increases erythrocyte ability to change the shape, improves the rheological properties of red cell emulsion, increases energy processes, utilization of glucose in erythrocytes, its resistance from peroxidase effects, normalizes indicators of immune status.