Polyshko T. Vaginal flora and microflora in normal conditions and under dysbacteriosis: their modeling and correction

It was shown, that mainstream tendentions of women under disbacteriosis were decreasing of lactobacilli quantity, increasing of conditionally-pathogenous bacteria quantity and, primarily, staphylococci; meanwhile, index aerobic bacteria to anaerobic bacteria was decreased too. The dysbacteriosis model of the vagina of mice was made by intravaginal introduction of antibiotics, microbial suspensions and the application of immunosuppressor. The dynamic qualitative and quantitative composition of microflora of the vagina in the formation of dysbacteriosis was displayed. It was also shown that there were no principal differences in the microflora of the vagina of women and mice, what, consequently, would make it possible to extrapolate the obtained data model. Comparative study of integrative indicators of staphylococci energy metabolism, a bacteria that prevailed in quantitative terms at dysbacteriosis, showed that in group 2 - staphylococci were isolated at dysbacteriosis, activation of oxidative processes associated with the intensification of the formation convertible energy sources compared to staphylococci of strains of the control group. Stydying of efficacy of correction shemes showed that most effective correction sheme was injection of two probiotic preparates: jn 1st stage - "Biosporin" and on 2nd stage - "Vagilac".