Sherstiuk S. Pathological anatomy of organs of the endocrine system of stillborn and children the dead under age 1, from the HIV-infection mothers

The dissertation is devoted to defining characteristics of the endocrine system organs in stillborn and children that were dead before 1 year old from the HIV-infected mothers on the basis of pathomorphological study of adenohypophysis, thyroid, adrenals, pancreas, gonads based on the morphofunctional state of the placenta. Maternal HIV-infection during pregnancy caused severe changes in the endocrine system of the fetus which revealed disturbance of embryogenesis and the consequent inhibition of the functional state of the entire population endocrine cells in the adenohypophysis except thyreotropocytes and the consequent inhibition of the morphofunctional activity of the adrenal glands, endocrine pancreas units, gonads and increased secretory activity of the thyroid gland. Established that postnatal ontogenesis of the endocrine system in children of HIV-infected mothers characterized by discoordination of the compensatory mechanisms in the form of low secretory activity endocrine cells of the adenohypophysis and manifested in inhibition of the peripheral endocrine glands functional activity, which ultimately lead to the breakdown of compensatory-adaptive processes and undoubtedly played a huge role in thanatogenesis. It is proved that HIV infection of the mothers lead to the morphogenesis disturbance in the fetal endocrine system (massive expansion of the stroma, inhibition of epithelial cell populations), causing their dysfunction. The data obtained allow us to explain the mechanism of tanatogenesis, state newborn violation of the functional activity of the endocrine glands in the transition to extrauterine existence, justify the need for at-risk groups on the development of severe endocrine dysfunction children from HIV-infected mothers.