Novytska I. Pathogenetic aspects of dysfunction of the salivary glands and their role in development of dental disease and ways of correction (experimental clinical research).

Based on epidemiological studies found that reducing salivation observed in 67.2 % of the population of Ukraine. First it is proved that the negative factors of the environment is not the direct cause of a violation of functional activity of the salivary glands, however, provide indirect influence on the development of somatic diseases, leading to a salivary glands dysfunction. For the first time various mechanisms to reduce the functional activity of the salivary glands, associated with disruption processes of saliva forming and salivation, which allows to optimize the treatment and prevention of dental disease in people with sialoschesis. Developed and tested "atropine" sialoschesis model and confirmed experimentally reproduce. Developed and tested in experiment and clinic new compositions with the effect of artificial saliva: remineralizing gel "Slyurem" and anti-inflammatory gel "Zoleh" and proved their high caries preventive and periodontal protective efficacy. It is shown that the proposed use of therapeutic and preventive complexes for persons with sialoschesis of different genesis enhance the functional activity of the salivary glands, improving the hygienic condition of the mouth, reduce the activity of inflammation in periodontal and oral mucosa, reduce the prevalence of hyperesthesia and have high caries preventive effect.