Zelenetsky I. Dysplastic hip syndrome in children by the inherited predisposition (genesis, diagnostic and treatment tactics)

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0515U000127

Applicant for

Specialization

  • 14.01.21 - Травматологія та ортопедія

06-02-2015

Specialized Academic Board

Д 64.607.01

State institution "Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine"

Essay

The object of study - the dysplastic hip joint pathology in children due to genetic predisposition. Objective: to develop the concept of dysplastic hip joint pathology in children due to genetic predisposition, to reveal her syndromological essence, to define the features of its course and justify a differentiated approach to the diagnosis and treatment strategy. Methods: in the theoretical part was used a systematic approach, the method of conceptual modeling, classification and terminology activities criterial synthesis and integrative principle multiform. In the empirical part of the paper used in clinical examination, radiation diagnosis, iridobiomikroskopy, mathematical and statistical methods. For the first time, built a general conceptual model of the dysplastic hip joint pathology in children due to genetic predisposition, on the principles of integration multiform and criterial synthesis. First settled and built a conceptual model of dysplastic syndromes of the hip in children caused by hereditary predisposition: dysplastic hip joint instability syndrome, dysplastic necrosis syndrome and dysplastic epiphysiolysis of the femoral head. Disclosed their genesis, clinical entity, typological features and determine their sequence flow. First constructed and proved the concept of dysplastic syndromes of the hip in children, based on the principle of an integrated approach, that allowed to reveal the essence of three separate diseases of childhood (congenital hip dislocation, Perthes disease and youthful epiphysiolysis femoral head) by one common causal factors - dysplastic abnormalities the structure of the hip, caused by hereditary predisposition, and pathogenetic syndromes multiform (distortion, compression, destruction), which arise depending on their qualitative and quantitative relationships. For the first time, on a mathematical model of the hip joint using of Mechanics and Mathematics and the finite element method to study the effect of anatomical abnormalities of hip components for its stability, the stress distribution in the femoral head. Improved classification of hip instability, depending on its degree of dysplastic changes and hip dislocation identified rаdiological. Developed and justified algorithmic system diagnostics and complex therapeutic measures in the case of dysplastic syndromes of the hip joint. The developed concept is essential to the practice of orthopedics, namely opens a new view of the problem of joint disease as a set of consecutive syndromes with their multiform anatomical and biomechanical relationships; significantly improves the differential diagnosis of dysplastic hip joint diseases; allows you to choose a differentiated surgical treatment aimed at addressing the root causes of syndromes and their consequences; defines a favorable prognostic aspects of treatment. Improved basis for estimating the results of surgical treatment of dysplastic syndromes hip allows you to define new indicators. Using the proposed system diagnostic and therapeutic tactics dysplastic hip joint pathology helps in the early stages of the disease to identify anatomic changes of its elements in interaction with each other and undertake appropriate remedial measures to the restoration of anatomy and function, prevent the development of deformations, destructive changes and childhood disability. Application of the developed device for the treatment of congenital dislocation of the hip in children (patent of Ukraine № 6540) improves the results of conservative treatment. The results of the research are introduced into clinical practice of municipal health agency "Kharkov regional clinical hospital trauma", Lugansk, Khmelnitsky, Kherson, Sumy, Mukachevo regional children's clinical hospital, SI "Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine", Ukrainian Research Institute of Prosthetics, Prosthesis and rehabilitation, and in the learning process of opthopedics departments of Kharkov Medical Academy of Postgraduate Education Ministry of Health of Ukraine and Kharkov State Medical University, Ministry of Health of Ukraine. Traumatology and Orthopedic.

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