Osokina O. The first episode of psychosis in patients with schizophrenia: clinical-psychopathological, psychological and personal-existential recovery of social functioning

The thesis is devoted the actual problems of modern psychiatry - the restoration of social functioning in patients with first psychotic episode of schizophrenia. This based on a comprehensive study of psychopathology prodromal and psychotic periods of illness, psychological, existential and cognitive resources of the individual, the development of multi-factor mathematical model predicting the clinical and functional outcomes of disease, concepts and systems of existential-personal rehabilitation of patients. There was studied the clinical and psychopathological structure of the first psychotic episode in patients with schizophrenia, as well as the clinical features of the prodromal stage of disease. There was defined factors that have the greatest impact on the prognosis of the first psychotic episode.there was examined the characteristics and impact on social functioning and quality of life such characteristics as a level of insight, psychological defense mechanisms, coping behavior, personal orientation, level of emotional distress and selfstigmatization in patients as well as the degree of meaningfulness and existential fullness of their lives. The electrophysiological markers of clinical status in first psychotic episode patients and features of their cognitive functioning were studied by registering evoked potentials of the brain. On the basis of this scientifically research the concept and the system of existential-personal rehabilitation in first psychotic episode patients were developed. There was evaluated the effectiveness of this system.