Bodnar G. Clinical Pathogenetic Particulars of Large Intestine Pathologies in Children with Dolichosigmoid: Paradigms of Diagnostics and Treatment

The dissertation is dedicated to the solution of a topical issue in Pediatrics - the improvement of diagnostics and treatment efficiency of organic and functional pathologies within the large intestine in children having a congenital elongation of the sigmoid colon. The research presents an in-depth study of pathogenetic mechanisms causing the development of functional and organic intestinal diseases. The dissertation studies the clinical course regularities of a congenital elongation of the sigmoid colon depending on the existence of a functional or organic intestinal pathology and compensatory ability of the child's body. The research has revealed immunological, microbiological, metabolic, intoxication and element markers of the functional and organic condition of the large intestine in children with a congenital elongation of the sigmoid colon.The condition of colonic motility has been defined. Morphological metastructure examination of all the layers of the sigmoid colon having a congenital elongation in children has been conducted. Based on the analysis of the received data, algorithms of diagnostics and differentiated treatment of functional and organic disorders of the large intestine in the presence of dolichosigmoid have been developed. The offered algorithms ensure highly efficient diagnostics and treatment of patients with the chronic constipation syndrome caused by a congenital elongation of the sigmoid colon from the very first manifestations of the disease to substantiated indications related to the choice of conservative therapy, as well as the prevention of decompensation development and complications of the pathologic process.