Gorokhivskiy V. Pathogenetic substantiation of correction processes in bone remodeling and prevention of complications in orthodontic treatment of children with dental fluorosis

It is shown that an excess of fluoride in drinking water leads to genetic disorders of collagen formation, increased prevalence of periodontal tissue diseases, tooth-jaw anomalies, deterioration of bone tissue. Experimental studies on the combined model of fluorosis and orthodontic tooth movement showed that an excess of fluoride in drinking water leads to poor blood parameters, reduction of nonspecific resistance, significant changes in the proteolysis of bone activity of osteoblasts and osteoclasts. Designed prophylactic complex largely normalized violated processes. Comprehensive prevention accompany orthodontic treatment of children with dental fluorosis provided caries preventive efficacy 66.67%, improved hygiene and periodontal indices, decreased the number of spontaneous detachments of braces, normalized biochemical and biophysical parameters of oral liquid, increased acid resistance of tooth enamel and its electrical resistance, decreases permeability barrier of the gums.