Logvinova O. Bronchopulmonary dysplasia in children: risk of development, prediction and prevention of outcomes.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0515U000899

Thesis Registration Form

0515U000899.pdf

Applicant for

Specialization

  • 14.01.10 - Педіатрія

23-10-2015

Specialized Academic Board

Д 64.600.04

Essay

BPD morbidity among premature children in Kharkiv region over the period of 2007-2014 has increased from 2.01% to 14.98%. AA polymorphism of MMP-1 gene (1607insG) induces disease formation, inhibition of arteriolo- and angiogenesis of the lungs and reparation of pulmonary parenchyma due to activation of TGF-?1, reduction of VEGF. With aging in children with Aa and aa variants of MMP-1 gene (1607insG), TGF-?1 and VEGF blood serum level tend to be within the normal range and, on the contrary, in case of AA variant stagnation of plasm TGF-?1 and VEGF indices is observed. The research findings have become the basis for introduction of effective suitable for application algorithms of prognosis and prevention of outcomes of bronchopulmonary dysplasia.

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Files

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