Ulyanova N. High axial myopia: pathogenesis, diagnosis, prevention and treatment (clinical and experimental study)

Object - hight axial myopia. Purpose: improvement of treatment in patients with myopia by the development of differ-entiated approach system to early diagnosis, prevention and treatment based on the study of pathogenetic significance of disregulatory disorders, including the characteristics of genetically determinate metabolism, the immune system, congenital and acquired psycho-emotional features of patient. Methods: clinical, psychological, morpholigical, genetic; funduscope, spectral optical coherence tomograph, microscop. It was proposed disregulatory hypothesis of myopia. Supplemented scientific data about the morphological dissociation plexiform retina layers in high axial myopia. The mechanisms of myopic foveoschisis formation was mathematically described and the method for its prediction was proposed. It was proposed the new way of determination of the optic disc morphometric parameters according to the spectral optical coherence tomography. The features of psycho-emotional status were investigated, and the algorithm of psychological support of patients with progressive myopia was proposed. It were deteminated genetic markers of rapid progression of myopia. The results introduced into the clinical practice of The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine; Vinnytsya Pirogov Memorial Clinical Hospital; Odesa Clinical Hospital № 4; Ophthalmology Departments of the Vinnytsya National Pirogov Memorial Medical University, Odesa and Kharkiv National Medical Universities. Fields of application - medicine, ophthalmology.