Demydenko G. Pathogenetic background of diagnosis and correction of cardiometabolic disturbances in patients with essential hypertension and type 2 diabetes.

The Dissertation represents a new approach to the diagnosis of cardiometabolic risk on the basis of estimation of pathogenetic role and prognostic significance of adipokines, immune inflammatory and angiogenesis factors, biomarkers of endothelium functional state, lipid and carbohydrate profile, heart remodeling in the development of comorbid pathology, disglicemia correction in patients with essential hypertension with type 2 diabetes. The influence of hyperglycemia, insulin resistance, abdominal type of obesity on the level of adipokine apelin, vascular endothelial growth factor, vasoactive nitric oxide pool state, immune inflammation level in patients with comorbid state has been determined. The character of structural and functional changes of the heart, as well as the influence of oncostatin M on left ventricle remodeling in patients with essential hypertension and concomitant type 2 diabetes have been ascertained. Pleiotrophic effects of metformin in patiens with comorbidity of essential hypertension and type 2 diabetes have been evaluated. The dynamics of carbohydrate and lipid profiles, adipokine apelin, angiogenesis and immune inflammation factors, remodeling of the heart have been estimated in patients with essential hypertension and concomitant type 2 diabetes during the treatment with metformin. The basic determinants of comorbidity of essential hypertension and prediabetes / type 2 diabetes have been distinguished. Mathematical model of cardiometabolic disturbances progression have been developed with corresponded calculation of type 2 diabetes developing risk in patients with essential hypertension.