Kushkevych I. The functional role of sulfate-reducing bacteria in the development of the intestinal diseases of humans and animals

The physiological and biochemical properties of sulfate-reducing bacteria (SRB) isolated from the intestine of humans and animals were studied. The conception of the functional role of SRB in the development of the intestines of humans and animals was created. It is based on the ability of these microorganisms in the process of dissimilatory sulfate reduction to form toxic metabolites that are a prerequisite of diseases of the colon. The cluster, correlation, cross-correlation and variance analysis based on the parameters of growth, consumption of sulfate and lactate, accumulation of sulfide and acetate, was carried out. The described experimental results are particularly useful for more detailed study of inflammatory bowel disease with the use of a therapeutic strategy. Determination of the SRB number and concentrations of sulfide and acetate made it possible to develop the basic criteria for assessing the aggressiveness of the bacteria, toxic products of their metabolism for the intestinal mucosa as well as assessing the level of risk of disease and course of the inflammatory process.