Bondarenko S. Synthesis and properties of benzopyrone alkaloid mimics.

The thesis devoted to the searching and development of approach for the synthesis of benzopyrone alkaloid mimetics and determination of perspective bioregulators among them. The ability and features of application of Mannich reaction with multifunctional amines and alkaloids, alkylation of amines and NH-heterocycles, and reductive amination for conjugation of benzopyrone core with nitrogen-containing fragment by methylene linker. The procedures of synthesis of alkaloid mimetics were performed for alkoxymethyl bridged fragments. The methods of conjugation of benzopyrone and nitrogen-containing moieties with C - C bond and syntheses of nirtogen-containing fused heterocyclic systems. Screening of focused libraries of bioactive compounds allows to select leader for future pre-clinic testing, as well as drug candidates for development of new antineoplastic and psychotropic agents. The perspectives of developed approaches for the synthesis of benzopurone alcaloid mimetics were confirmed by biologocal screening.