Mykhailiuk P. Fluorine-containing amino acids, amines and diazoalkanes

For the first time was performed the design and the synthesis of series of fluorine-containing mono- and bicyclic conformationally restricted amino acids as labels for 19F NMR replacement of natural amino acids residues. For the first time it was developed a reliable procedure for obtaining multigram quantities of three isomeric C-(2.2.2-trifluoroethyl)anilines and practical approach to all three isomers of (3.3.3-trifluoropropyl)anilines. For the first time it was developed the in situ generation of diverse diazoalkanes followed reaction with alkenes/alkynes is an effective route towards pyrazoles and pyrazolines with different fluorine-containing substituents.