Orysyk S. Coordination chemistry of series 3d, 4d-metals with ambident functional substituted hydrazides, imines and carbothioamides

Important scientific problem of coordination chemistry related to regio- and stereoselective synthesis of 3d, 4d-metals coordination compounds based on ambidentate ligands ? functionally substituted hydrazides, imines and carbothioamides was solved in the thesis. As a result, 185 novel mono-, bi- and polynuclear complexes with different types coordinated ligands were obtained. The patterns of ligand coordination depending on mutual geometrical arrangement of functional groups and heterocycles in ligand molecules were studied. The influence of electron-donor and electron-acceptor substituents in molecules of O, N, O-containing hydrazides on В (electronic repulsion parameter) of ?(C=N) and stability of Ru (III), Rh (III) complexes was studied. The instability constants of Ru (III) and Rh (III) complexes with hydrazide derivatives were determined and a corresponding row of stability of the synthesized compounds was built. The influence of ligands tautomerism and pH of reaction mixture on the formation of a mono-, bi- or polynuclear complexes of transition metals was studied. The influence of carbothioamides tautomerism on formation of the corresponding geometry of the Ni (II) coordination polyhedron was determined. The extraction-photometric method for identification and successive separation of Ru(III), Rh(II) and Pd(II) ions at their joint presence in solution was designed. The influence of such compounds on mitotic cycle of HeLa cells in comparison with cisplatin was studied. It was shown that complex [Pd(Z-H2L15)Cl2] is the most perspective for further investigations "in vivo".