Prysyazhnyuk V. Clinical-pathogenic, age and genetic aspects of chronic diffuse liver diseases, comorbid processes and hypothyroidism, differentiated approaches of treatment

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0518U000152

Thesis Registration Form

0518U000152.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

06-06-2018

Specialized Academic Board

Д 35.600.05

Danylo Halytsky Lviv National Medical University

Essay

The thesis deals with the improvement of diagnostic and treatment efficiency of patients with non-alcoholic fatty liver disease (NAFLD) and nonviral chronic hepatitis (CH), taking into account clinical-pathogenic, age, gender and genetic factors and the presence of hypothyroidism. Clinical-pathogenic, age, gender and genetic peculiarities of clinical course of NAFLD and CH were determined. NAFLD patients with subclinical and manifested hypothyroidism are characterized by torpid NAFLD clinical course, higher activity of markers of cholestasis, proatherogenic changes of the lipid profile, adipokine imbalance and decreased insulin resistance syndrome. On the basis of the obtained data, the treatment process was improved by L-carnitine added to basic therapy in NAFLD and CH patients, resulting in more effective improving the immediate and long-term results of treatment. Industry - medicine.

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Files

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aref.doc

dis.doc

dis.doc

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