The Object is the process of theoretical and methodological foundations formation of the sustainable innovation development system support of winemaking enterprises. The Purpose is theoretical and methodological substantiation, deepening of conceptual positions and development of scientific and practical recommendations concerning system support of sustainable innovation development of winemaking enterprises. The Methods of Research are of systematic structural analysis and synthesis, taxonomic analysis and nonparametric statistics, matrix, expert estimates, dynamic norms, cognitive analysis. Theoretical and practical results lie in the fact that the theoretical positions of the thesis were brought to the level of specific methods and recommendations. The recommendations substantiated in the dissertation can be used by organizations and institutions of the field of viticulture and winemaking, investors and other enterprises of the wine-growing and wine-making complex to determine possible scenarios of sustainable innovation development of winemaking enterprises. Scientific novelty is in theoretical and methodological substantiation, deepening of conceptual positions and development of scientific and methodological approaches to the systematic support of sustainable innovation development of winemaking enterprises. The degree of implementation is expressed in the results, conclusions and proposals which received positive feedback and were used in the practice of state bodies, scientific organizations and domestic industrial enterprises: The Department of Business Development and Regulatory Policy of the Ministry of Economic Development and Trade of Ukraine (certificate number 3633-06 / 43134-07 dated November 24, 2017); The Department of Agrarian Policy of the Odessa Regional State Administration (certificate numbers 02/83 and 78/02/82 dated January 25, 2018); National Scientific Center "Institute of Viticulture and Winemaking named after V.E. Tairov" (certificate number 710 dated December 13, 2017); Economic Academy of Moldova, professor, doctor of economics E. Feurash (review dated April 19, 2018); PJSC "Odessa Factory of Champagne Wines" (certificate number 764 dated June 9, 2017); Vinogradnaya dolina LLC (certificate number 266 dated December 29, 2017); PJSC "Odesavinprom" (certificate number 76 dated February 19, 2018); PJSC "Odessa Cognac Factory" (certificate number 61 dated May 19, 2017); Shabo LLC (certifacate number №266 dated 29.12.2017); S-Engineering LLC (certifacate number 01/10-11 dated November 10, 2017); Nikolaev Cognac Factory LLC (certificate number 75 dated February 19, 2018); PJSC "Koblevo" (reference number 1152 dated April 5, 2018); Scientific and Technical Enterprise "Plant-Win", Moldova (certificate number 74 dated April 19, 2018). The materials of the dissertation research (theoretical, methodical and practical author's developments) were introduced into the educational process of the Odessa National Academy of Food Technologies of the Ministry of Education and Science of Ukraine (Act of Implementation № 262 dated December 29, 2017). The Sphere (industry) of use is the economy and management of enterprises (by types of economic activity).