Chornous V. 5-Carbofunctionalized 4-chloro-1Н-imidazoles: synthesis, structural modification and biological properties

The thesis is devoted to the development of a methodology for the synthesis of new chemotypes of 5-carbo-functionalized 4-chloro-1H-imidazole, and their directed structural modification for the design of bioactive systems. Preparationally convenient methods for the synthesis of 5-formyl-4-chloro-1H-imidazole by the interaction of N-alkyl (aryl) glycinamide, N-aroyl-N-alkyl (aryl) glycinamide and imidazolidine-2,4-dione with the Vilsmeier-Haack reagent were developed. Conditions of the directed functionality of the imidazole core by the pharmacophoric groups in the positions 2,4 and 5 have been developed. Compounds with anti-tuberculosis, antioxidant, hypoglycemic activity were found.