Havrylenko Y. Clinical and laboratory diagnostics and treatment of chronic pharyngeal diseases of children suffering from diabetes mellitus type 1

The dissertation is devoted to solving an important scientific problem of improving the quality of early diagnosis and the effectiveness of treatment of chronic pharyngeal diseases of children suffering from type 1 diabetes mellitus by studying the clinical and laboratory features of the course of the disease and the application of complex therapy. The study involved 707 children with type 1 diabetes mellitus aged 3 to 18, boys – 365 (51,6 %), girls – 342 (48,4 %). It was established that the frequency of the disease in this contingent of patients with chronic tonsillitis (33,6 %) depends on the level of glycemic control and is not related to the duration of the disease, which indicates the general pathogenetic orientation of the damage to palatine tonsils in them. On the basis of conducted microbiological and cytological research from crypts of palatine tonsils, the leading role of microbial associations in the pathogenesis of chronic tonsillitis in the formation of immune inflammation has been proved, their influence on the indices of local immunity has been determined. The changes in the psycho-emotional state and the significant violations of the microcirculatory channel indexes according to the correlation analysis in children with chronic tonsillitis against the background of type 1 diabetes mellitus have been determined. Experimental studies have identified changes in the thymus, spleen, visceral lymph nodes, nasal associate lymphoid tissue, and the pronounced immunomodulatory effect of the BNO 1030 medication on the restoration of their cellular structure, increased immune cell viability and tissue energy processes. It is scientifically substantiated and proved that the most effective method of conservative treatment of chronic tonsillitis in children with type 1 diabetes is the combination of immunosuppression with the use of a non-specific immunomodulator BNO 1030 and a solution of povidon-iodine local action.