Голіченко О. Synthesis, structure and properties of rhenium(III) cluster compounds with biological activity

The dissertation focuses on the development of the basic principles and concrete ways of nonautoclave synthesis and interconversions of rhenium(III) binuclear halogenocarboxylates of all possible structural types, on the determination of the influence of synthesized compounds structures, on biological activity, and the determination of a biological action model of rhenium(III) cluster compounds by studying the processes of their complexation with the functional groups of substances included in the living organisms. With the help X-ray diffraction analysis data and other physico-chemical methods of research, it has been proved that the bridge coordination to the (Re2)6+ cluster unit through the Oxygen atoms is found the all investigated carboxylate ligands. The complex compound of rhenium(III) exhibits catalytic properties and acts as a "trap" of free radicals due to the presence of a quadruple Re-Re bond and the formation of intermediate complexes with a charge transfer. The dependence of the structure of dirhenium(III) complex compounds and anticarcinogenic activity was established. The obtained results allow us to conclude that one of the important reasons for the presence of anticancer and other biological activities is the coordination of Re(III) complex compounds with the components of biomolecules (proteins, DNA).