Luchitskiy V. Pathogenesis and treatment of erectile dysfunction in men with type 2 diabetes mellitus

Object of the research: erectile dysfunction and testosterone deficiency in men with type 2 diabetes mellitus. Aim of investigation: to improve the quality of diagnosis and effectiveness of treatment of these complications in patients with type 2 diabetes and type 2 diabetes, based on a comprehensive study of the etiologic and pathogenetic mechanisms of erectile dysfunction and testosterone deficiency in men with type 2 diabetes. combined with obesity. Methods of the investigation and equipment: general clinical, biochemical, enzyme immunoassay, radioisotope, instrumental and statistical; tomographic gamma camera of GSK 301 LT. Theoretical and practical results: identified the main pathogenetic factors of the formation of testosterone deficiency in men with type 2 diabetes mellitus and its role in the development of erectile dysfunction. type and erectile dysfunction. Studies have confirmed the effectiveness of the use of phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction in men with type 2 diabetes. It is recommended that the annual determination of androgens in the blood of men with type 2 diabetes. Novelty: the results of studies have allowed to expand the understanding of the main mechanisms of formation of pathogenetic factors for the development of testosterone insufficiency and erectile dysfunction in men with type 2 diabetes. The presence and mechanisms of microangiopathy development in the testes of men with type 2 diabetes, testosterone insufficiency and erectile dysfunction were first established. For the first time, the prerequisites for the use of aromatase inhibitors for the treatment of testosterone deficiency are substantiated. The degree of implementation: the results of the performed work are introduced into the healing process of the clinic of the State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism NAMS of Ukraine"and medical institutions of Ukraine. Areas of application: endocrinology, urology, andrology, sexology.