Object – the process of managing the entrepreneurship development on the imperatives of sustainable development in the information and innovation economy; purpose – development of theoretical and methodological basis and methodological provisions and recommendations for system-integrated management of business development on the imperatives of sustainable development in the information and innovation economy; methods – abstract-logical, morphological, retrospective analysis, classification-analytical, economic-statistical and comparative analysis, synthesis, multiple correlation services Microsoft Excel, graphical, empirical research and content analysis, logical-substantive modeling, structuring and description, field research, SWOT -analysis and grouping, functional synthesis and formalization, economic and statistical, panel expert assessments, questionnaires, logical; novelty – is the development and scientific substantiation of the theoretical and methodological basis and methodological provisions and recommendations for system-integrated management of business development on the imperatives of sustainable development in the information and innovation economy; results – is the development scientifically substantiated and methodically completed recommendations for system-integrated management of business development on the imperatives of sustainable development, implemented at ALC "Pervomaiskdieselmash" (reference № 26/281/1 dated March 12, 2020); LLC "IPG Master" (reference №16-03 dated March 16, 2020); LLC "Finansova kompaniya FK «Herts»" (reference № 20/03-15/07 dated March 15, 2020); scientific and methodological tools of the dissertation were introduced by: the Verkhovna Rada Committee of Ukraine, on Finance, Tax and Customs Policy (letter № 1209/67-07 dated 14.02.2020, reference № 04-32/8-2020/115673 dated July 22, 2020); Bilhorod-Dnistrovsky Employment Center (letter № 1210/67-07 dated 14.02.2020, reference 1432/07-26/01 July 17, 2020); State Scientific Institution "Institute for Modernization of the Content of Education" of the Ministry of Education and Ukraine Science (reference № 1/4-34-17 dated September 26, 2019); Charitable Foundation "Caritas Odessa UGCC" in partnership with the Representation of the International Organization for Migration in Ukraine project "Strengthening self-sufficiency of internally displaced persons and communities affected by the conflict in Ukraine" (reference № 18-116 dated December 04, 2018); Caritas Ukraine International Charitable Foundation in the implementation of the project "Sustainable economic recovery for peace" (reference № 138/1 from November 23, 2018); The results of the dissertation are used in the educational process of Odessa National Polytechnic University in teaching materials on the disciplines "Incubation and acceleration of small business", "Modern trends in business and business environment", "Management of socially-oriented projects", "Socio-ecological and economic principles of sustainable development "and diploma design of masters (implementation certificate dated December 26, 2019).