Nechytailo D. Early detection of arterial hypertension in schoolchildren by assessing the functional state of the cardiovascular system, with identification of the risk factors for the development of this pathology and with the formation of risk groups

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0520U101840

Applicant for

Specialization

  • 14.01.10 - Педіатрія

22-12-2020

Specialized Academic Board

Д 76.600.02

HSEE of Ukraine "Bukovinian State Medical University"

Essay

Object - arterial hypertension and arterial prehypertension in school-age children; goal - to improve the diagnosis and prediction of the development of arterial hypertension in schoolchildren on the basis of targeted screening examination of children with the selection of risk factors and the formation of risk groups for the development of this pathology; methods - clinical, sociometric, anthropometric, instrumental, determination of the balance of the autonomic nervous system according to the Kerdo index, statistical; results - new criteria for the formation of the risk group of children for the development of arterial hypertension; risk factors for the development of arterial hypertension in schoolchildren were identified for the first time on the basis of analysis of anthropometric, sociometric and clinical-instrumental research methods and their significance was established; expanded the idea of ​​the role of peripheral resistance and relationships between indicators of peripheral and central hemodynamics in the identification of a number of predictors of microcirculatory factors (reduced number of capillaries per unit area (OR = 2.54; 95% CI [2.06-4.98]) , increased pathological tortuosity of capillaries (OR = 1.75; 95% CI [1,18-2,63])), which may be the basis for the formation of arterial hypertension in childhood; new data on the peculiarities of daily fluctuations of blood pressure in schoolchildren with arterial hypertension were obtained, the phenomenon of "night peak" of systolic blood pressure was registered for the first time and circadian markers of arterial hypertension in these children were isolated; proposed and substantiated the need to use the method of infrared thermography with a cold test and proved its effectiveness in schoolchildren to assess the intensity of peripheral blood flow and detect microcirculation disorders in the complex diagnosis of hypertension; An algorithm for early diagnosis of arterial hypertension in schoolchildren was developed and tested, taking into account possible hyper- and hypodiagnostics.

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