Burlaka A. Metabolic and stromal predictors of the metastatic colorectal cancer with metachronous liver injury: control of the early progression, substantiation of the combined therapy approach

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0521U100206

Thesis Registration Form

0521U100206.pdf

Applicant for

Burlaka Anton Anatoliyovich

Specialization

14.01.07 - Онкологія

Date of defense

03-03-2021

Specialized Academic Board

Д 26.560.01

National Cancer Institute

Essay

A dissertation presents an approach dedicated to solve an urgent problem of oncology, improved oncological prognosis in patients with metastatic liver disease with colorectal cancer (CRC) through the use of parenchyma-preserving surgical strategy (PPS) and the study of redox-dependent predictors of the early progression. The work based on 3 fragments, including an in vivo study (95 C57BL mice and 35 Wistar rats), a retrospective study (analysis of 285 clinical cases of liver resections in case of metastatic CRC) and a prospective study involving 185 CRC patients with metastatic liver disease.

Thesis supervisor