Kamenshchyk A. Prognostic value of genetic, biochemical, immunological and hemodynamic factors in left ventricular remodeling in children with bicuspid aortic valve

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0521U100389

Thesis Registration Form

0521U100389.pdf

Applicant for

Specialization

  • 14.01.10 - Педіатрія

24-03-2021

Specialized Academic Board

Д 17.600.02

Zaporizhzhya State Medical University

Essay

The dissertation is devoted to improving the prediction of left ventricular myocardial remodeling in children with bicuspid aortic valve. The influence of polymorphism and expression оf NFATC1 gene, the prognostic value of proteins of the calcineurin signaling pathway (calcineurin, protein S100) on the formation of myocardial hypertrophy, was established. The value of immunological parameters (CD25⁺, CD95⁺) in the pathogenesis of pathological changes in the aortic valve was determined. Decreased tolerance to exercises was found. On the basis of the obtained data the concept of remodeling of the left ventricular myocardium in this category of children was proposed.

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autoreferat-Каменщик А.В._Автореферат.pdf

Каменщик А.В._Дисертація.pdf

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