Kuleshov O. Risk factors for mitral valve prolapse incidence and prediction in children and peculiarities of its correction

The thesis is devoted to settling a topical medical, social and scientific issue of predicting the outcomes of the clinical development of the mitral valve prolapse (MVP) in children by virtue of the identification of differential and diagnostic differences as compared to left ventricular false tendons, determination of factors of dysrhythmia manifestations and development of intracardiac hemodynamics, as well as elaboration of the adequate approach to effective treatment and outpatient follow-up of risk groups, considering the response to physical exertion. The peculiarities of the clinical development of the mitral valve prolapse in children as compared to left ventricular false tendons have been found. The structure of the cardiac dysrhythmias and the peculiarities of vegetative nervous system disorder with prevailing sympathicotonia in the examined children have been described. The early signs of the left ventricular diastolic dysfunction, which were more marked with MVP, have been found in the examined children. The role of the physical exertion in determination of the latent impairments of intracardiac hemodynamics in children with MVP has been substantiated. Considering the above mentioned, three risk groups were determined; moreover, children with MVP can be under the high risk of complications development, irrespective of the initial degree of prolapse. The algorithm of the treatment-differentiated approach to the outpatient follow-up of children with various manifestations of MVP has been elaborated. Key words: children, mitral valve prolapse, left ventricular false tendons, vegetative dysfunction, prediction of complications, physical exertion, risk groups, treatment