Object - the process of managing business processes of the enterprise on the basis of their review; purpose - is to develop a theoretical and methodological grounds and guidelines and recommendations for safety-oriented management of smartization of business processes of an industrial enterprise; methods - structural-logical analysis, scientific abstraction, systematization, generalization, concretization and comparative analysis, historical-logical analysis, comparative-legal, methodical methods of tabular and graphical presentation of research results, grouping, scaling, theoretical generalization, economic-statistical and regression analysis , expert evaluations, methods of optimization, systematization and mathematical models (granding, O*NET, method of Hay's profile tables, strategic maps); novelty - consists in the development and scientific substantiation of the theoretical and methodological basis and methodological provisions and recommendations for safety-oriented management of smartization of business processes of an industrial enterprise; results - scientifically substantiated and methodically completed recommendations on introduction of safety-oriented management of smartization of business processes of the industrial enterprise; introduced PJSC "EXIMNAFTOPRODUKT" (reference № 17-45 from 11.12.2018), LLC "Alatex" (reference № 341k from 15.01.2019), LLC "C-engineering" (reference № 02/23-04 from April 23, 2019), TECHNOCHEM LLC (reference № 15 dated May 14, 2019), Meirtt Group Sp. z o.o. Ltd. (reference № 5/1/10/2019 dated 01.10.2019), SE “Dniprovsky Electric Locomotive Plant” (reference № 1/23 dated 23.10.2019), LLC “EPT PLAST” (reference № 56/2/k from 20.02.2020), LLC "Vinogradna Dolyna" (reference № 18 from 26.02.2020), the Committee of the Verkhovna Rada of Ukraine on Education, Science and Innovation of the Verkhovna Rada of Ukraine (letter № 5-ov/2020 from 01.06.2020), Department of Ecology and Natural Resources of the Odessa Regional State Administration (letter № 5341/04-24/5248 dated November 1, 2019), Scientific and Production Association "Ukrbiopreparat" (reference №3/41 from 14.09.2018), LLC Scientific and Production Society "Ecology" (reference № 175/06 from 10.06.2019); in the educational process of Odessa National Polytechnic University of MES of Ukraine in diploma design, in the preparation of disciplines: "Theory of security of social systems", "Staffing of financial and economic security of the enterprise", "Organization and management of financial and economic security", "Risk Management", "Information and analytical support of economic security", "Training course: Information support of project management", "Innovative technologies of management decision-making" (certificate of implementation act № 648 / 82-07 from 30.04.2020).