Purpose: theoretical and methodological substantiation of scientific bases of the social and economic systems development process from a position of branch and regional approaches, development of national economy structural balance functioning practical tools formation. Object: processes of transformational changes in the system of the national economy, which ensure the sustainable development structural balance. Subject: theoretical and conceptual positions, methodological, scientific-methodical and applied principles of forming the national economy sustainable development structural balance. Methods of research: epistemological and content analysis; analysis, synthesis, systems approach and scientific abstraction; construction of concepts and categories; economic-statistical and comparative analysis; institutional analysis; economic and mathematical modeling; graphic modeling; survey and expert evaluation; graphic visualization; abstract-logical. Theoretical results: theoretical and methodological bases of national economy sustainable development structural balance formation have been developed. Practical results: possibilities of Ukraine economy systemic improvement on the basis of the developed conceptual and theoretical bases, scientific and methodical recommendations and methodology of the national economy sustainable development structural balance formation have been substantiated. Scientific novelty: an explication of the definition “socio-economic systems development” has been developed, the concept of the socio-economic system sustainable development structural balance has been formulated and methodologically substantiated, the model of institutional support of the national economy sustainable development structural balance mechanism formation has been designed, it has been improved: systematization of the category “development” terminological range use by dynamic and structural characteristics with the selection of development effectiveness key factors, positioning of the “sustainable development” concept goals in terms of basic structural elements and their complementarity at macro-, meso- and micro-levels, methodological approach to substantiation of the national economy structural changes directions,
. directions of structural changes in the national economy, methodological and applied approaches to justify the conditions for building strategic partnerships in the field of "green entrepreneurship", received further development: identification of dynamic properties of socio-economic systems, targets of methodology for analyzing the institutional environment potential of the national economy, methodical and applied approaches to substantiation of strategic partnership in the field of “green business” development terms; received further development: identification of dynamic properties of socio-economic systems, target settings of methodology of the country institutional environment analysis, methodological approach to substantiation of national economy resource potential directions development. Degree of implementation: Khmelnytskyi Regional State Administration, Department of Development of Agro-Industrial Complex and Land Relations of Khmelnytskyi Regional State Administration, Khmelnytskyi Chamber of Commerce and Industry, NGO “Council of Young Scientists at the Ministry of Education and Science of Ukraine”, NGO “Institute for Democracy and Social Progress”, Khmelnytskyi regional organization of the Union of Economists, enterprises of various spheres and organizational and legal forms of activity, Khmelnytskyi National University. Efficiency: the study results contribute to the formation of national economy sustainable development structural balance. Scope of application: specialized ministries and administrations, central and local executive authorities, sectoral authorities, business structures and higher educational institutions.