Shyshkin O. Molecular structure and conformational analysis of six-membered dihydrocycles

The main rules of molecular structure of six-membered dihydrocycles have been established. It was demonstrated that all types of rings posses high conformational flexibility. An influence of electronic and steric substituent effects and anneletaion by various rings on conformational characteristics of partially hydrogenated rings have been studied. Intermolecular interaction effects in the crystal phase and their influence on conformation of flexible rings have been investigated. It was show that high conformational flexibility of six-membered dihydrocycles may essentially change physico-chemical properties of compounds especially in biological systems.