Maksiv K. The role of genetic and metabolic factors in the pathogenesis of arterial hypertension combined with chronic obstructive pulmonary disease

Dissertation is devoted to establishing the specific features of free radical oxidation and antioxidant protection and their dependence on polymorphisms in the genes of angiotensin-converting enzyme and angiotensinogen as part of mechanisms behind the course of COPD with comorbid arterial hypertension. This research paper has supplemented the scientific evidence on the specific features of oxidative stress and antioxidant protection in patients with comorbid COPD and hypertension. The work has detailed scientific evidence on the prevalences of alleles and genotypes based on I/D polymorphism in the ACE gene and the М235Т polymorphism in the AGT gene. Patients with a concomitant course of COPD and hypertension were found to have a trend towards higher prevalence of the D/D genotype of the ACE gene. It was established the highest ACE activity in patients with combined COPD and arterial hypertension. It was analyzed the relationship between ACE I/D and AGT М235Т gene polymorphisms and the parameters of free radical oxidation and antioxidant protection in patients with comorbid COPD and arterial hypertension. The ACE and AGT gene polymorphisms were not found to have any statistically significant correlations with the oxidative stress and the glutathione system. In the meantime, substantial differences were found between oxidative stress and glutathione system parameters in patients of various test groups within one genotype of ACE and AGT genes.