Viun T. Prognostic value of bone mineral density modulators in patients with combined chronic pancreatitis and arterial hypertension.

According to the results of the dissertation, scientifically substantiated results have been obtained, and they solve a specific task for internal medicine - the increase of the diagnosis and prediction efficiency of osteopenic conditions in patients with chronic pancreatitis in combination with hypertension by determining biochemical markers of bone mineral density (serum calcium, total acid phosphatase, osteocalcin and tartrate-resistant acid phosphatase) and the prevalence of lactase gene (LCT), vitamin D receptor (VDR) as well as farnesyldiphosphate synthase (FDPS) polymorphisms. Examination of patients revealed the features of the clinical course of chronic pancreatitis in patients with hypertension. The scientific data on the diagnostic value of studies of the indicators of bone metabolism (total and ionized serum calcium, total acid phosphatase, tartrate-resistant acid phosphatase, osteocalcin) in these patients have been clarified and supplemented. The prevalence of polymorphism of candidate genes LCT, VDR and FDPS, changes in which determine the predisposition to the formation of osteopenic states has been specified. The correlations between biochemical parameters of bone metabolism and polymorphism of genes - markers of osteoporosis - in patients with a combined course of chronic pancreatitis and hypertension, which allows to predict the formation of osteodeficiency have been studied. Based on the determination of the most prognostic markers of bone mineral density, a research diagnostic algorithm for predicting the development of secondary osteoporosis in patients with chronic pancreatitis on the background of hypertension has been developed.